Anti-age Check Up

What is an Anti-age Check Up?

It is a diagnostic test that allows one to determine the biological age of all the organs and systems of the organism. The biological age, as opposed to the chronological age, characterizes the health condition of a person with the utmost precision.

Determining the biological age enables eliciting:

• the state of all vital functions with consideration for future changes;
• the range of adaptation – the resilience of the organism to different external factors – low and high temperatures, changes in the atmospheric pressure, lack of oxygen, electromagnetic influence activity, etc.;
• the probability of the occurrence of different diseases.

Anti-age Check Up in "Kivach" Clinic

The specialists of the clinic have designed a special program to determine the biological age, which includes an extensive list of examination methods. This program assesses the metabolic, structural, functional, regulatory, adaptive and genetic characteristics cumulatively.

This allows for:

• obtaining a full objective picture of the age-related changes of the organism;
• making an accurate prognosis on the development of the age-related changes with consideration for the most probable consequences;
• recognizing dangerous diseases in early stages as well as liability to them;
• assessing the degree of the negative impact of external factors (such as the environment, the lifestyle, the unhealthy habits, the diet, etc.) on the organism.

What is the Anti-age Check Up program for?

The program is recommended for people over 40 years old. At this age, it is essential to stay physically active. However, natural age-related changes of the organism begin at the age of 25 on average. They tend to accumulate eventually, thus preventing one from being highly active.

The Anti-age Check Up program identifies all of the scientifically proven individual factors that influence the aging process. Based on this program, the specialists develop a complex of recommendations. These recommendations have the form of a list of practical measures aimed to:

• control and manage current illnesses, to the extent of reaching a stable remission;
• lower the risk of developing a genetic disease;
• prevent diseases conditioned by external circumstances (viruses, technogenic factors, etc.);
• correct the lifestyle to overcome the existing external and internal factors of aging (the patient will receive recommendations on physical activity, sports choice, diet, place of residence, etc.)

Following these recommendations will allow for extension of the expectancy of life and maintaining its active phase for as long as possible, furthermore saving the external attractiveness, physical endurance and fitness for working.

What does the Anti-age Check program include?

This program includes:

• medical consultation by physicians, cardiologists, ophthalmologists, ENT specialists, gastroenterologists, dieticians, as well as gynecologists (for women) and urologists-andrologists (for men);
• more than 50 instrumental and laboratory methods of examination, including science-intensive innovative technology;
• individual recommendations.

Molecular genetic testing

Several gene groups are examined to determine the liability to dangerous diseases – hypertensive disease, diabetes, atherosclerosis, Alzheimer’s disease, osteoporosis, oncology diseases, etc. If corresponding liability is found, the risk of developing the disease rises with age.

During the analysis, one of the present risk levels is determined, of which there are six. This scale allows for making a timely decision about the necessity and nature of medical intervention, which will lower or eliminate the risk of developing a dangerous condition completely.

Following the results of the molecular genetic testing, a full genetic profile of the patient is compiled.

Latent food intolerance testing

This examination determines food components that, if consumed, negatively impact the patient’s health. In the process, those micronutrients that lead to inflammatory reactions and tissue damage are determined

The test is based on the methodology called “Immunohealth”, which enables the specialists to form a list of food products, as well as product groups related to them, that are dangerous for consumption on an individual basis. Based on this analysis, an elimination diet is designed, which is a nutrition regimen that cleans the organism of elements that cause the development of various pathologies.

Blood test through the chromatography-mass spectrometry method

This examination identifies the presence of microbial markers – chemical components that are formed as a result of the activity of microorganisms. This method is highly reliable; it allows for determining the kinds of the pathogenic microorganisms that have caused the inflammatory process and recognizing latent infections that are not active at this moment.

Enzyme-linked immunosorbent assay (ELISA)

This examination shows the presence of autoantibodies in blood, which are special cells produced by the organism as a reaction to a pathological process. These autoantibodies appear long before the first symptoms of the disease. Identifying them allows for determining the risk of developing diseases of the following organs and systems in early stages:

• nervous system;
• immune system;
• cardiovascular system;
• liver;
• kidneys;
• lungs;
• gastrointestinal tract;
• thyroid gland;
• pancreas gland;
• prostate gland;
• adrenal glands.

EPR-test (electronic paramagnetic resonance)

This is a method of examination that recognizes oncological pathologies in early stages. The analysis can determine the configuration of albumen – the protein that performs the transporting function and takes part in binding and eliminating of endotoxins. The appearance of an oncological pathology in the organism entails particular changes in the configuration of albumen. The electronic paramagnetic resonance method can register these specific changes and identify them.

Evaluation of the antioxidant activity of the organism (MOS-1)

This analysis evaluates the state of the antioxidant system of the organism. This system inhibits the formation of free radicals and repairs their damage to cell structures. Its decreased activity leads to what is referred to as oxidative stress, which is the prime cause of accelerated ageing, immunodeficiency, hormonal disorders, malignant tumor development, etc.

Interleukin 6 (IL-6) test

This examination determines the ability of the organism to synthesize interleukin 6. This component is produced by special cells (macrophages and T cells) and stimulates an immunological response to infectious, inflammatory processes and traumatic tissue injuries. A low level of interleukin 6 reduces the protective functions of the organism.

Insulin-like growth factor 1 (IGF-1) test

The test determines the concentration of the insulin-like growth factor. There are certain (referential) quantities that are normal for people of different ages. A higher or lower concentration of IGF-1 indicates the presence of a pathology. For instance, a high concentration of IGF-1 signifies a high level of somatotrophin (growth hormone), which entails enlargement of internal organs (heart, for example) as well as type 2 diabetes mellitus, cardiovascular diseases, arthritis and a shorter life expectancy.

25-hydroxyvitamin D, vitamins В1, В3, В5, В6, active vitamin В12 and folic acid test

This test identifies the concentration of vitamins in blood to make up the deficit if necessary. Vitamin deficiency raises the risk of developing diseases that depend on the patient’s age – stroke, myocardial infarction, cardiac insufficiency, autoimmune pathologies, senile psychosis, etc.

Examination through the polymerase chain reaction (PCR) method

This is a high-technology examination method aimed to identify causative agents of infectious diseases. It allows for determining and identifying harmful microorganisms with precision by small fragments of their DNA.

Full list of examination methods

Consultations by specialists

• physician;
• cardiologist;
• ophthalmologist;
• ENT specialist;
• gastroenterologist;
• dietician (including forming an individual diet plan).

Molecular genetic testing

A full genetic health profile (an extensive interpretation in written form).

Laboratory methods of examination

• Clinical blood analysis.
• Carbohydrate metabolism parameters: glucose, glycated hemoglobin, insulin.
• Liver function parameters: ALT, AST, total bilirubin, direct bilirubin, alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT).
• Kidney function parameters: urea, creatinine.
• Lipid profile: total cholesterol, triglycerides, low-density lipoproteins, high-density lipoproteins, lipoprotein (a).
• Omega-3 index test.
• Metabolic process parameters: uric acid.
• Electrolytes: potassium, sodium, chlorine.
• Bone tissue parameters: total calcium, ionized calcium, parathormone, calcitonin.
• Inflammatory process parameter: C-reactive protein (CRP), high sensitivity assay.
• Haemocoagulative parameters: prothrombin, fibrinogen, APTT.
• Indicators of iron status: ferritin.
• Amino acid level test: homocysteine.
• Allergic reaction and antiparasitic activity parameter: total immunoglobulin E.
• 25-hydroxyvitamin D, vitamins В1, В3, В5, В6, active vitamin В12 and folic acid test.
• Insulin-like growth factor 1 (IGF-1) test.
• Interleukin 6 (IL-6) test.
• Evaluation of the antioxidant activity of the organism (MOS-1): malondialdehyde, 8-oh-deoxyguanosine, coenzyme Q10, vitamin E (tocopherol), vitamin C (ascorbic acid), beta-carotene (provitamin A), glutathione.
• Hormone tests:
  • Prolactin, luteinizing hormone (LH).
  • Estradiol saliva test.
  • Progesterone saliva test.
  • Testosterone saliva test.
  • DHEA-S saliva test.
  • Cortisol saliva test.
  • Thyroid body function parameters and thyroid hormones: thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4), anti-thyroid peroxidase antibodies (anti-TPO antibodies).
• EPR-test (electronic paramagnetic resonance) (early malignant tumor detection).
• Tumor markers: CA 15-3; CA 19-9, CA 72-4, CEA.
• Enzyme-linked immunosorbent assay (ELISA).
• Latent food intolerance testing «Immunohealth».
• Hepatitis blood tests:
  • Hepatitis B surface antigen (HBsAg);
  • Anti-hepatitis-C antibodies (Anti-HCV-total).
• HIV and syphilis blood tests:
  • Anti-HIV-1/2 antibodies;
  • Total anti-Treponema pallidum antibodies (anti-tr.pallidum IgG/IgM).
• Blood tests for viruses:
  • Anti-cytomegalovirus antibodies (IgM, IgG);
  • Anti-Epstein-Barr Virus capsid antibodies (IgM, IgG).
• Examination through the polymerase chain reaction (PCR) method:
  • Human papilloma virus (HPV) analysis of high oncogenic risk, quantitative screening of 15 types (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68).
• In-depth diagnosis of infection and inflammatory processes – blood test through the chromatography–mass spectrometry method.
• Helminth stool test (counting method).
• Lamblia antigen stool test.
• Hair test for toxic and vital microelements.

Instrumental methods of examination

• Electrocardiography.
• Ultrasound investigation of abdominal cavity organs.
• Ultrasound investigation of kidneys.
• Ultrasound investigation of thyroid body.
• Cardiac ultrasound.
• Triplex scanning of brachiocephalic arteries.
• Triplex scanning of lower extremity veins.
• Anteroposterior digital radiography of thoracic cavity organs.
• Esophagogastroduodenoscopy under sedation and urea test.
• Fibro colonoscopy under sedation.
• Bioelectrical impedance analysis.

Additional examination methods for women

• Consultation by a gynecologist.
• Clinical urine analysis.
• Tumor markers: CA-125, HE-4.
• Follicle-stimulating hormone (FSH).
• International normalized ratio blood test.
• Bone formation marker P1NP.
• Bacterial flora smear microscopy.
• Papanicolau test.
• Real-time urogenital tract flora screening (PCR method). Femoflor (13+sampling control).
• Extended videocolposcopy.
• Ultrasound of breasts and regional lymph nodes.
• Transvaginal ultrasound of pelvic organs.

Additional examination methods for men

• Consultation by a urologist-andrologist.
• Three-glass urine test.
• Tumor markers: total and free PSA, chorionic gonadotropic hormone.
• Sex hormone-binding globulin (SHBG)
• Prostatic fluid smear microscopy.
• Ultrasound of pelvic organs (TRUS of prostate with Doppler sonography).
• Tumor marker PCA3 (specific tumor marker of prostate cancer).